External otitis caused by infection with Pseudomonas aeruginosa or Candida albicans cured by use of a topical group III steroid, without any antibiotics. Acta oto-laryngologica. [Acta Otolaryngol] Journal article | | Title | External otitis caused by infection with Pseudomonas aeruginosa or Candida albicans cured by use of a topical group III steroid, without any antibiotics. | | Author(s) | Emgård P, Hellström S, Holm S | | Institution | ENT Clinic, Ystad Hospital, Ystad, Sweden. per.emgard@skane.se | | Source | Acta Otolaryngol 2005 Apr; 125(4):346-52. | | MeSH | Administration, Topical
Animals
Anti-Bacterial Agents
Betamethasone
Candidiasis
Colony-Forming Units Assay
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Therapy, Combination
Ear Canal
Hydrocortisone
Male
Otitis Externa
Oxytetracycline
Polymyxin B
Pseudomonas Infections
Rats
Research Support, Non-U.S. Gov't
Treatment Outcome
| | Abstract | CONCLUSIONS: Irrespective of the microbial agent, group III steroid solution cured external otitis efficiently in a rat model. The addition of antibiotic components to steroid solutions for the treatment of external otitis is of questionable validity.
OBJECTIVE: External otitis, caused by infection with either Pseudomonas aeruginosa or Candida albicans, was established in a rat model and the treatment efficacy of a group III steroid solution was studied.
MATERIAL AND METHODS: Three treatments were studied: (i) a group III steroid solution; (ii) a group I steroid combined with two antibiotic components; and (iii) a saline solution. A scoring scale was used to evaluate the characteristics of the ear canal skin. Bacteriological and fungal samples were collected for culturing and ear canal skin biopsies were taken for structural analyses.
RESULTS: It was possible to cause P. aeruginosa and C. albicans infections in an animal model. In the P. aeruginosa-infected animals, only the group III steroid treatment cured all the animals. In the C. albicans-infected animals, group III steroid treatment resolved external otitis faster than the other treatment modalities. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 15823803 |
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