| Title | No increase in rates of early-onset neonatal sepsis by antibiotic-resistant group B Streptococcus in the era of intrapartum antibiotic prophylaxis. | | Author(s) | Chen KT, Puopolo KM, Eichenwald EC, Onderdonk AB, Lieberman E | | Institution | Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. ktc10@columbia.edu | | Source | Am J Obstet Gynecol 2005 Apr; 192(4):1167-71. | | MeSH | Age of Onset
Anti-Bacterial Agents
Antibiotic Prophylaxis
Bacteremia
Cohort Studies
Comparative Study
Drug Resistance, Bacterial
Female
Follow-Up Studies
Humans
Incidence
Infant, Newborn
Infant, Newborn, Diseases
Pregnancy
Pregnancy Complications, Infectious
Probability
Research Support, U.S. Gov't, P.H.S.
Retrospective Studies
Risk Assessment
Sex Distribution
Streptococcal Infections
Streptococcus agalactiae
| | Abstract | OBJECTIVE: The aim of this study was to assess the rate of early-onset neonatal sepsis by antibiotic-resistant group B Streptococcus.
STUDY DESIGN: The time-trend study was conducted at a tertiary care center over the following periods: no protocol for group B Streptococcus prophylaxis (1990 to 1992), risk-based protocol (1993 to 1996), and screening-based protocol (1997 to 2002).
RESULTS: A total of 120,952 neonates were born with 118 cases of group B Streptococcus early-onset neonatal sepsis. The rate of group B Streptococcus early-onset neonatal sepsis decreased significantly (from 2.0 to 1.1 to 0.4 per 1000 births, P < .0001). No group B Streptococcus isolate was resistant to ampicillin, penicillin, cefazolin, or vancomycin. From 1997 to 2002, there were 3 clindamycin-resistant group B Streptococcus isolates (14%). The rate of erythromycin-resistant group B Streptococcus early-onset neonatal sepsis did not change (from 0.14 to 0.03 to 0.08 per 1000 births, P = .6). However, cases of erythromycin-resistant group B Streptococcus early-onset neonatal sepsis accounted for an increasing proportion of the remaining cases of group B Streptococcus early-onset neonatal sepsis (from 7.0% to 2.6% to 23.8%, P = .07).
CONCLUSION: We found no increase in rates of antibiotic-resistant group B Streptococcus early-onset neonatal sepsis. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 15846197 |
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