Nizatidine versus placebo in gastroesophageal reflux disease. A six-week, multicenter, randomized, double-blind comparison. Nizatidine Gastroesophageal Reflux Disease Study Group. Digestive diseases and sciences. [Dig Dis Sci] Journal article | | Title | Nizatidine versus placebo in gastroesophageal reflux disease. A six-week, multicenter, randomized, double-blind comparison. Nizatidine Gastroesophageal Reflux Disease Study Group. | | Author(s) | Cloud ML, Offen WW | | Institution | Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285. | | Source | Dig Dis Sci 1992 Jun; 37(6):865-74. | | MeSH | Comparative Study
Double-Blind Method
Esophagitis, Peptic
Esophagoscopy
Female
Gastroesophageal Reflux
Heartburn
Humans
Male
Middle Aged
Nizatidine
Time Factors
Wound Healing
| | Abstract | In a randomized, multicenter trial, nizatidine 150 mg or 300 mg, or placebo, was administered twice daily for six weeks to 515 patients with gastroesophageal reflux disease (GERD). Gelusil antacid tablets were taken as needed for pain. Significantly superior rates of endoscopically proven complete healing (normal-appearing mucosa) versus placebo occurred after three weeks with nizatidine 150 mg, and after six weeks with nizatidine 300 mg. Six-week healing rates were 38.5% for nizatidine 300 mg, 41.1% for nizatidine 150 mg, and 25.8% for placebo. The nizatidine 150 mg treatment group had significantly greater improvement in daytime and nighttime heartburn severity after one day of therapy versus placebo. Twice-daily administration of nizatidine 150 mg or 300 mg provides prompt relief from the major symptom of GERD, heartburn, and complete healing of esophagitis is seen in many patients. | | Language | eng | | Pub Type(s) | Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
| | PubMed ID | 1587191 |
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