In vitro binding characteristics for cesium of two qualities of prussian blue, activated charcoal and Resonium-A. Journal of toxicology. Clinical toxicology. [J Toxicol Clin Toxicol] Journal article | | Title | In vitro binding characteristics for cesium of two qualities of prussian blue, activated charcoal and Resonium-A. | | Author(s) | Verzijl JM, Joore JC, van Dijk A, Glerum JH, Savelkoul TJ, Sangster B, van het Schip AD | | Institution | Ministry of Defense, Central Military Hospital, Utrecht, The Netherlands. | | Source | J Toxicol Clin Toxicol 1992; 30(2):215-22. | | MeSH | Cesium Radioisotopes
Charcoal
Ferrocyanides
Hemoperfusion
Hydrogen-Ion Concentration
In Vitro
Polystyrenes
| | Abstract | The in vitro binding characteristics of radioactive 137Cs to two forms of Prussian blue [colloidally (soluble) K3Fe[Fe(CN)6] and insoluble Fe4[Fe(CN)6]3] and to activated charcoal and sodium polystyrene sulfonate (Resonium-A) were investigated by constructing Langmuir isotherms at pH = 1.0, 6.5 and 7.5 at 37 degrees C. At the three pHs investigated, 137Cs binding to activated charcoal and sodium polystyrene sulfonate was negligible. Binding of 137Cs to insoluble Prussian blue exceeded that for the soluble form and was pH dependent for both formulations. Maximum binding capacities were 87 mg/g (pH = 1.0), 194 mg/g (pH = 6.5) and 238 mg/g (pH = 7.5) for the insoluble form and 48 (pH = 1.0), 73 (pH = 6.5) and 78 (pH = 7.5) for the soluble form. As activated charcoal did not bind 137Cs, charcoal hemoperfusion is of no value. This has been confirmed by an in vitro experiment, using a Gambro Adsorbs 300 C cartridge. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 1588671 |
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