| Title | [Quantitative analysis of serum troponin I and myoglobin in patients with acute myocardial infarction] | | Author(s) | Xiao HG, Huang ZH, Liu HX, Lin YP | | Institution | Department of Clinical Laboratory, Guangzhou Medical College, Guangzhou 510120, China. xiaohongguang610904@yahoo.com.cn | | Source | Di Yi Jun Yi Da Xue Xue Bao 2005 May; 25(5):550-1. | | MeSH | Aged
Biological Markers
Creatine Kinase
Creatine Kinase, MB Form
Female
Humans
Male
Middle Aged
Myocardial Infarction
Myoglobin
Troponin I
| | Abstract | OBJECTIVE: To investigate the clinical implications of cardiac troponin I (cTnI), myoglobin (Mb), creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) in patients with acute myocardial infarction (AMI).
METHODS: The serum concentrations of cTnI and Mb were determined in 50 patients with AMI 2 to 4 h after chest pain onset and compared with those measured in 50 age-matched healthy subjects.
RESULTS: The serum levels of cTnI, CK-MB and CK in patients with AMI were significantly higher than those in the control group. Mb levels in AMI group were above the normal range. Mb, CK-MB, CK and cTnI reached the peak levels at 8+/-2.2, 18.1+/-3.2, 19.4+/-4.1 and 18.6+/-2.9 h after the onset, respectively, and their levels increased with the aggravation of AMI and were reduced to the normal levels with the amelioration of the disease. All the 4 indices were normal in the control group.
CONCLUSION: cTnI and Mb are reliable biochemical markers for early diagnosis of AMI and the changes in their serum levels have clinical significance in diagnoses and prognostic judgment of AMI. | | Language | chi | | Pub Type(s) | English Abstract
Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 15897132 |
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