| Title | Esomeprazole tablet vs omeprazole capsule in treating erosive esophagitis. | | Author(s) | Chen CY, Lu CL, Luo JC, Chang FY, Lee SD, Lai YL | | Institution | Division of Gastroenterology, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan, China. | | Source | World J Gastroenterol 2005 May 28; 11(20):3112-7. | | MeSH | Administration, Oral
Adult
Aged
Anti-Ulcer Agents
Capsules
Double-Blind Method
Esophagitis, Peptic
Female
Heartburn
Humans
Male
Middle Aged
Omeprazole
Prospective Studies
Research Support, Non-U.S. Gov't
Tablets
| | Abstract | AIM: Esomeprazole, an oral S-form of omeprazole, has been a greater acid inhibitor over omeprazole in treating acid-related diseases. Only less published data is available to confirm its efficacy for Asian people. Therefore, a perspective, double-blind, randomized comparison of esomeprazole tablets 40 mg (Nexium) vs omeprazole capsules 20 mg (Losec) in treating Chinese subjects with erosive/ulcerative reflux esophagitis (EE) was conducted.
METHODS: A total of 48 EE patients were enrolled and randomized into two treatment groups under 8-wk therapy: 25 receiving esomeprazole, while another 23 receiving omeprazole treatment. Finally, 44 completed the whole 8-wk therapy.
RESULTS: The difference in healing EE between two groups was 22.7% (72.7% vs 50.0%), not reaching significant value (P = 0.204). The median of the first time needed in relieving heartburn sensation was 1 d for both groups and the remission rates for heartburn on the 1st d after treatment were 77.3% and 65%, respectively (NS). The scores of various reflux relieving symptoms evaluated either by patients or by investigators were not different. Regarding drug safety, 28% of esomeprazole group and 26.1% of omeprazole group reported at least one episode of adverse effects, while constipation and skin dryness were the common side effects in both groups (NS).
CONCLUSION: Esomeprazole 40 mg is an effective and safe drug at least comparable to omeprazole in treating Chinese EE patients. | | Language | eng | | Pub Type(s) | Clinical Trial
Journal Article
Randomized Controlled Trial
| | PubMed ID | 15918199 |
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