Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes research and clinical practice. [Diabetes Res Clin Pract] Journal article | | Title | Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. | | Author(s) | Park HS, Park JY, Yu R | | Institution | Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea. hyesoon@amc.seoul.kr | | Source | Diabetes Res Clin Pract 2005 Jul; 69(1):29-35. | | MeSH | Abdomen
Adipose Tissue
Adult
Biological Markers
Body Mass Index
C-Reactive Protein
Cross-Sectional Studies
Female
Humans
Interleukin-6
Korea
Male
Obesity
Regression Analysis
Research Support, Non-U.S. Gov't
Tumor Necrosis Factor-alpha
| | Abstract | OBJECTIVE: To investigate the relationship between serum concentrations of the cytokines C-reactive protein (CRP), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-6, and obesity and visceral adiposity.
METHODS: A cross-sectional study of 100 Korean adults free from pre-existing inflammatory disease or cancer was performed. Body mass index (BMI), waist circumference, and serum concentrations of CRP, TNF-alpha and IL-6 were measured. In 46 obese subjects, fat mass was assessed by bioimpedance analysis and abdominal fat distribution was determined by computerized tomography scan.
RESULTS: Overall, serum concentrations of CRP, TNF-alpha and IL-6 were significantly correlated with weight, BMI, waist circumference, hip circumference, and waist-hip ratio. In obese subjects, CRP and IL-6 were significantly correlated with BMI, waist circumference and visceral adipose tissue. Multiple regression analysis showed that CRP was significantly associated with BMI, whereas IL-6 was significantly related with visceral adiposity in obese subjects.
CONCLUSIONS: The positive associations of obesity and visceral adiposity with elevated cytokine levels suggest the importance of reducing obesity and visceral adiposity to prevent elevations in cytokine levels. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 15955385 |
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