| Title | Nutritional vitamin B12 deficiency: two cases detected by routine newborn urinary screening. |
| Author(s) | Michaud JL, Lemieux B, Ogier H, Lambert MA |
| Institution | Department of Paediatrics, Hôpital Sainte-Justine, Côte Ste-Catherine, Montréal, Québec, Canada. |
| Source | Eur J Pediatr 1992 Mar; 151(3):218-20. |
| MeSH | Breast Feeding
Female
Humans
Infant
Infant, Newborn
Male
Methylmalonic Acid
Mothers
Neonatal Screening
Vitamin B 12
Vitamin B 12 Deficiency
|
| Abstract | We describe two asymptomatic newborns with nutritional vitamin B12 deficiency in whom increased urinary methylmalonic acid was detected by routine neonatal screening at 3 weeks of age. Both infants were exclusively breast-fed. One mother suffered from pernicious anaemia, and the other was a strict vegetarian. Both mothers had no clinical or haematological abnormality, aside from a borderline mean corpuscular volume for the vegetarian mother. This report illustrates the early appearance of functional vitamin B12 deficiency in breast-fed infants of vitamin B12-depleted mothers. It also demonstrates that urinary methylmalonic acid measurement is a sensitive indicator of tissue vitamin B12 deficiency. |
| Language | eng |
| Pub Type(s) | Case Reports
Journal Article
|
| PubMed ID | 1601016 |
