| Title | Comparison of dobutamine stress echocardiography with and without real-time perfusion imaging for detection of coronary artery disease. | | Author(s) | Xie F, Tsutsui JM, McGrain AC, Demaria A, Cotter B, Becher H, Lebleu C, Labovitz A, Picard MH, O'Leary EL, Porter TR | | Institution | University of Nebraska Medical Center, Omaha, Nebraska, USA. | | Source | Am J Cardiol 2005 Aug 15; 96(4):506-11. | | MeSH | Albumins
Cardiotonic Agents
Comparative Study
Contrast Media
Coronary Angiography
Coronary Arteriosclerosis
Dobutamine
Echocardiography, Stress
Female
Fluorocarbons
Follow-Up Studies
Humans
Infusions, Intravenous
Male
Middle Aged
Myocardial Contraction
Observer Variation
Pilot Projects
Reproducibility of Results
Research Support, Non-U.S. Gov't
Severity of Illness Index
| | Abstract | In a pilot study of 27 patients, those who presented with chest pain underwent 2 dobutamine stress echocardiographic studies, 1 with high mechanical index harmonic imaging to analyze wall motion without contrast and 1 with real-time low mechanical index perfusion imaging with intravenous Optison to assess myocardial perfusion and wall motion. All patients then underwent quantitative coronary angiography. Two independent reviewers demonstrated an improvement in sensitivity when analyzing myocardial perfusion. In the 21 patients who had significant coronary stenoses, 14 had abnormal myocardial perfusion detected at peak stress and 7 had abnormal wall motion detected by standard dobutamine stress echocardiography. There was decreased specificity with perfusion imaging by 1 reviewer. The addition of real-time perfusion imaging after intravenous contrast during dobutamine stress echocardiography has the potential to improve detection of coronary artery disease. | | Language | eng | | Pub Type(s) | Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
| | PubMed ID | 16098301 |
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