Does contrast echocardiography induce increases in markers of myocardial necrosis, inflammation and oxidative stress suggesting myocardial injury? Cardiovascular ultrasound [electronic resource]. [Cardiovasc Ultrasound] Journal article | | Title | Does contrast echocardiography induce increases in markers of myocardial necrosis, inflammation and oxidative stress suggesting myocardial injury? | | Author(s) | Knebel F, Schimke I, Eddicks S, Walde T, Ziebig R, Schattke S, Baumann G, Borges AC | | Institution | Universitätsmedizin Berlin, Medical Clinic for Cardiology, Angiology, Pulmology, Charité Campus Mitte, Germany. fabian.knebel@charite.de | | Source | Cardiovasc Ultrasound 2005.:21. | | MeSH | Adolescent
Adult
Albumins
Contrast Media
Cytokines
Echocardiography
Female
Fluorocarbons
Humans
Male
Middle Aged
Myocarditis
Oxidative Stress
Risk Assessment
Risk Factors
Thiobarbituric Acid Reactive Substances
| | Abstract | BACKGROUND: Contrast echocardiography is a precise tool for the non-invasive assessment of myocardial function and perfusion. Side effects of contrast echocardiography resulting from contrast-agent induced myocardial micro-lesions have been found in animals. The goal of this study is to measure markers of myocardial necrosis, inflammation and oxidative stress in humans to evaluate potential side-effects of contrast echocardiography.
METHODS: 20 patients who underwent contrast echocardiography with Optison as the contrast medium were investigated. To evaluate myocardial micro-necrosis, inflammation and oxidative stress, cardiac troponin I (cTnI), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, -8 and thiobarbituric acid reactive substances (TBARS) were measured at baseline and at 2, 4, 8 and 24 hours after contrast echocardiography.
RESULTS: At baseline, 50% of the patients had cTnI and TBARS values outside the reference range. TNF-alpha, IL-6, IL-8 levels were within the reference range. Patients with cTnI above the RR clustered to significantly higher levels of TNF-alpha and IL-6. After contrast echocardiography, no statistically significant increase of cTnI, cytokines and TBARS was found. However, for nearly 50% of the patients, the intra-individual cTnI kinetics crossed the critical difference (threefold of methodical variation) which indicates a marker increase. This was neither predicted by the baseline levels of the cytokines nor the markers of oxidative stress.
CONCLUSION: There are no clinically relevant increases in serum markers for micro-necrosis, inflammation and oxidative stress in humans after contrast echocardiography. Future studies have to address whether cTnI increase in some patients represent a subset with increased risk for side effects after contrast echocardiography. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 16107209 |
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