The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis. European journal of clinical pharmacology. [Eur J Clin Pharmacol] Journal article | | Title | The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis. | | Author(s) | Tracy TS, Krohn K, Jones DR, Bradley JD, Hall SD, Brater DC | | Institution | Department of Medicine, Indiana University School of Medicine, Indianapolis 46202. | | Source | Eur J Clin Pharmacol 1992; 42(2):121-5. | | MeSH | Adult
Anti-Inflammatory Agents, Non-Steroidal
Arthritis, Rheumatoid
Blood Proteins
Choline
Comparative Study
Female
Humans
Ibuprofen
Kidney
Male
Metabolic Clearance Rate
Methotrexate
Middle Aged
Naproxen
Protein Binding
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Salicylates
| | Abstract | We have studied the pharmacokinetics of methotrexate in patients with rheumatoid arthritis concurrently treated with choline magnesium trisalicylate, ibuprofen, naproxen, or a non-NSAID analgesic (control treatment). The apparent systemic clearance of methotrexate was significantly reduced by all three treatments. Trisalicylate and ibuprofen both significantly reduced methotrexate renal clearance, but only the trisalicylate significantly displaced methotrexate from protein, increasing the fraction unbound by 28%. These data show that NSAIDs can affect the disposition of methotrexate, possibly increasing the potential for toxicity and necessitating dosage adjustments. However, large inter-subject variability precludes specific dosage recommendations. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 1618240 |
|
|
| |
Advertise on this site.
| | |
|
