[The prevalence of metabolic syndrome in middle-aged in Kaunas population] Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] Journal article | | Title | [The prevalence of metabolic syndrome in middle-aged in Kaunas population] | | Author(s) | Gustiene O, Slapikas R, Klumbiene J, Sakalauskiene G, Kubilius R, Bagdzeviciūte S, Zaliūnas R | | Institution | Clinic of Cardiology, Kaunas University of Medicine, Kaunas, Lithuania. olivija.gustiene@gmail.com | | Source | Medicina (Kaunas) 2005; 41(10):867-76. | | MeSH | Adult
Age Factors
Blood Glucose
Body Mass Index
C-Reactive Protein
Cardiovascular Diseases
Comparative Study
Cross-Sectional Studies
Data Interpretation, Statistical
English Abstract
Female
Humans
Lipoproteins, HDL Cholesterol
Lithuania
Male
Metabolic Syndrome X
Middle Aged
Obesity
Questionnaires
Risk Factors
Sex Factors
| | Abstract | AIM: To assess the prevalence of the metabolic syndrome among middle-aged Kaunas population.
MATERIAL AND METHODS: A total of 433 (192 males and 241 females, mean age 38.8+/-0.3 years) asymptomatic individuals have been investigated. Metabolic syndrome was diagnosed using International Diabetes Federation definition criteria - central obesity (the waist circumference > or =94 cm for men and > or =80 cm for women) plus any two of the following four factors: elevated triglycerides (Tg) (> or =1.7 mmol/L), low high-density lipoprotein cholesterol (HDL-C) levels (<1.0 mmol/L for men and <1.3 mmol/L for women), blood pressure (BP) of 130/85 or higher (systolic pressure >130 mmHg or a diastolic pressure >85 mmHg) or hyperglycemia (> or =5.6 mmol/L).
RESULTS: The metabolic syndrome was present in 21.7% (28.1% among males and 16.6% among females) of individuals. Furthermore, 41.1% had an increased waist circumference, 56.4% had elevated BP (130/85 or higher), 31.2% had elevated plasma glucose concentration, 19.9% had low HDL-C cholesterol values and 14.1% had increased Tg values. Significantly higher concentration (1.16 mg/L, alpha<0,001, beta<0.001) of high-sensitivity C-reactive protein has been established in individuals with the metabolic syndrome. An increased concentration (>3 mg/L) of high-sensitivity C-reactive protein was more prevalent (17.3%) in the cohort with metabolic syndrome. Concentration of high-sensitivity C-reactive protein directly correlated with the waist and hips circumference, body mass index, concentration of Tg, glucose and BP.
CONCLUSIONS: The prevalence of the metabolic syndrome among middle-aged Kaunas residents was 22%. Metabolic syndrome and central obesity correlated with elevated concentration of high-sensitivity C-reactive protein. Moderately (1-3 mg/L) and severely (>3 mg/L) elevated high-sensitivity C-reactive protein levels increase the chance of metabolic syndrome by 4.15 and 7.39 times, respectively (p=0,000). An innovative approach towards cardiovascular risk assessment integrating traditional cardiovascular risk factors, metabolic syndrome and high-sensitivity C-reactive protein values could improve the risk stratification in asymptomatic middle-aged population. | | Language | lit | | Pub Type(s) | Journal Article
| | PubMed ID | 16272835 |
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