Autonomic nervous system functions in children with breath-holding spells and effects of iron deficiency. Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] Journal article | | Title | Autonomic nervous system functions in children with breath-holding spells and effects of iron deficiency. | | Author(s) | Kolkiran A, Tutar E, Atalay S, Deda G, Cin S | | Institution | Ankara University, Medical School, Department of Paediatric Cardiology, Ankara, Turkey. | | Source | Acta Paediatr 2005 Sep; 94(9):1227-31. | | MeSH | Arrhythmia, Sinus
Autonomic Nervous System
Child, Preschool
Comparative Study
Electrocardiography
Female
Ferritin
Heart Rate
Humans
Infant
Iron
Male
Parasympathetic Nervous System
Respiration Disorders
Syncope
| | Abstract | AIM: To analyse the activity of the autonomic nervous system during breath-holding spells, we assessed the ECG changes, including ventricular repolarization parameters before and during the spell. We also analysed the effects of iron deficiency on these ECG parameters.
METHODS: The study group consisted of 37 children with breath-holding spells (30 cyanotic, 7 pallid) (mean age+/-SD: 12.9+/-10.8 mo). Twenty-six healthy children (mean age+/-SD: 14.4+/-8.6 mo) served as a control group. All patients and controls had standard 12-lead simultaneous surface ECG. All patients had ECG recordings during at least one severe breath-holding spell obtained by "event recorder". Traces obtained by "event recorder" were analysed in terms of mean heart rate and the frequency and duration of asystole during the spell.
RESULTS: Respiratory sinus arrhythmia on standard ECGs and asystole frequency during spells were higher in patients with pallid breath-holding spells. Patients with iron deficiency had a lower frequency of respiratory sinus arrhythmia and prolonged asystole time during the spell. There was no difference in terms of ventricular repolarization parameters (QT/QTc intervals and QT/QTc dispersions) between patients and controls and between patient subgroups (cyanotic versus pallid).
CONCLUSION: These results confirmed the presence of autonomic dysregulation in children with breath-holding spells. Iron deficiency may have an impact on this autonomic dysregulation. Ventricular repolarization was unaffected in patients with breath-holding spells. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 16278993 |
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