| Title | Optimal initial dose of orally administered cyclosporine following intravenous cyclosporine therapy. | | Author(s) | Ishizawa T, Sugawara Y, Ikeda M, Hasegawa K, Makuuchi M | | Institution | Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. | | Source | Transplant Proc 2005 Dec; 37(10):4370-2. | | MeSH | Administration, Oral
Adult
Comparative Study
Cyclosporine
Humans
Immunosuppressive Agents
Injections, Intravenous
Liver Transplantation
Middle Aged
Postoperative Period
Research Support, Non-U.S. Gov't
Retrospective Studies
| | Abstract | Conversion of the main immunosuppressive agent from tacrolimus to cyclosporine (CyA) is a valuable rescue therapy for the severe adverse effects of tacrolimus. We report our experience of the conversion in living donor liver transplantation, in which tacrolimus therapy was converted to CyA. There are few reports describing the optimal initial dose of orally administered CyA (PO CyA) after intravenously administered CyA (IV CyA). We retrospectively investigated the ratio of CyA blood concentrations at 12 hours after the initiation of PO CyA to that just before the conversion, and the ratio of the initial dose of PO CyA to the total dose of IV CyA administered during the 12 hours before the conversion. Linear regression analysis revealed a close correlation between these ratios (y = 2.7 + 5.8x, r = 0.73; P = .002). We recommend that, to maintain a similar trough level of CyA during conversion in liver transplantation, Neoral should be initiated at a ninefold greater dose than the total dose of IV CyA administered during the 12 hours before conversion. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 16387123 |
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