| Title | Clustering of metabolic abnormalities in adolescents with the hypertriglyceridemic waist phenotype. | | Author(s) | Esmaillzadeh A, Mirmiran P, Azizi F | | Institution | Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. | | Source | Am J Clin Nutr 2006 Jan; 83(1):36-46; quiz 183-4. | | MeSH | Adolescent
Adult
Anthropometry
Blood Glucose
Child
Cluster Analysis
Cross-Sectional Studies
Female
Health Surveys
Humans
Hypertension
Hypertriglyceridemia
Iran
Male
Metabolic Syndrome X
Obesity
Phenotype
Predictive Value of Tests
Prevalence
Prospective Studies
Research Support, Non-U.S. Gov't
Risk Factors
Sex Factors
Triglycerides
Waist-Hip Ratio
| | Abstract | BACKGROUND: It remains unknown whether the hypertriglyceridemic waist (HW) phenotype, an appropriate screening tool in adults, can also be used to screen for metabolic abnormalities in adolescents.
OBJECTIVE: We aimed to evaluate metabolic risk factors identified by the HW phenotype in adolescents.
DESIGN: Anthropometric and biochemical measurements were assessed in a population-based cross-sectional study of 1413 male and 1623 female Iranian adolescents aged 10-19 y. The HW phenotype was defined as serum triacylglycerol concentrations > or = 110 mg/dL and concurrent waist circumference > or = 90th percentile for age and sex. Elevated fasting glucose (> or = 110 mg/dL), high LDL (> or = 130 mg/dL) and low HDL (< or = 40 mg/dL) cholesterol, hypercholesterolemia (total cholesterol > or = 200 mg/dL), and hypertension (systolic or diastolic blood pressure > or = 95th percentile for age, sex, and height) were considered as risk factors.
RESULTS: Adolescents with the HW phenotype had significantly higher prevalences of all metabolic risk factors except elevated fasting glucose than did those without the HW phenotype. After control for potential confounding variables, adolescents with the HW phenotype were significantly more likely to have high LDL cholesterol (odds ratio: 1.8; 95% CI: 1.3, 2.7), low HDL cholesterol (1.6; 1.3, 2.0), hypercholesterolemia (2.9; 2.0, 4.2), and > or = 1 (1.4; 1.1, 1.7) and > or = 2 (2.2; 1.6, 3.0) risk factors than were those without the HW phenotype. The HW phenotype had a significantly higher percentage of correct prediction of metabolic abnormalities than did overweight, elevated triacylglycerol concentration, or enlarged waist circumference.
CONCLUSION: This study shows a clustering of metabolic abnormalities in adolescents with the HW phenotype and suggests this phenotype as a simple marker for identifying adolescents at risk of metabolic syndrome and other metabolic abnormalities. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 16400047 |
|
