| Title | Study of subclinical cerebral edema in diabetic ketoacidosis by magnetic resonance imaging T2 relaxometry and apparent diffusion coefficient maps. | | Author(s) | Figueroa RE, Hoffman WH, Momin Z, Pancholy A, Passmore GG, Allison J | | Institution | Neuroradiology Section, Department of Radiology, Medical College of Georgia, 1120 15th street, Augusta, GA 30912, USA. rfiguero@mail.mcg.edu | | Source | Endocr Res 2005; 31(4):345-55. | | MeSH | Adolescent
Blood Chemical Analysis
Brain Edema
Child
Diabetic Ketoacidosis
Humans
Magnetic Resonance Imaging
| | Abstract | Cerebral edema is the most significant complication in children with diabetic ketoacidosis (DKA). Our goal was to study whether subclinical cerebral edema was preferentially vasogenic or cytotoxic. Magnetic resonance imaging (MRI)--diffusion-weighted imaging (DWI) and T2 relaxometry (T2R)--were obtained in pediatric patients presenting with severe diabetic ketoacidosis (DKA) 6-12 hours after initial DKA treatment and stabilization and 96 hours after correction of DKA. T2 relaxometry was significantly increased during treatment in both white and gray matter, in comparison to the absolute T2R values 96 hours after correction of DKA (p = .034). Classic intracellular cytotoxic edema could not be detected, based on the lack of a statistically significant decrease in ADC values. ADC values were instead elevated, implying a large component of cell membrane water diffusion, correlating with the elevated white and gray matter T2R We discuss the findings in relation to cerebral blood volume, cerebral vasoregulatory dysfunction, and cerebral hyperemia. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 16433253 |
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