| Title | Multicenter study of the efficacy and safety of subcutaneous non-animal-stabilized hyaluronic acid in aesthetic facial contouring: interim report. | | Author(s) | DeLorenzi C, Weinberg M, Solish N, Swift A | | Institution | The DeLorenzi Clinic, Kitchener, Ontario, Canada. delorenzi@golden.net | | Source | Dermatol Surg 2006 Feb; 32(2):205-11. | | MeSH | Adult
Aged
Biocompatible Materials
Cosmetic Techniques
Face
Female
Follow-Up Studies
Gels
Humans
Hyaluronic Acid
Injections, Subcutaneous
Male
Middle Aged
Prospective Studies
Skin Aging
Treatment Outcome
| | Abstract | BACKGROUND: Non-animal-stabilized hyaluronic acid (NASHA) gel may offer longer-lasting cosmetic correction and lower antigenic risk than other soft tissue augmentation agents.
OBJECTIVE: To assess the efficacy and safety of the NASHA gel Restylane SubQ (Q-Med AB, Uppsala, Sweden) in aesthetic facial contouring.
METHODS: Fifty-seven adult patients seeking cheek and/or chin augmentation received subcutaneous and/or supraperiostal injections of Restylane SubQ (20 mg/mL) at 114 treatment sites; 13 of these patients received "touch-up" injections at 20 sites. Efficacy was assessed subjectively using a 5-grade Global Aesthetic Improvement Scale at 1, 3, 6, 9, and 12 months after the initial treatment.
RESULTS: At 3 months post-baseline, patients and investigators independently considered the treatment sites to be improved in 96.4% and 100% of cases, respectively. Patient- and investigator-assessed response rates (proportion of patients showing moderate or better improvement) were 84% and 95%, respectively. The majority of reported adverse events were treatment related (local injection-site reactions, implantation complications, skin tightness, and skin induration), but these were generally of mild intensity and short-lived.
CONCLUSION: Restylane SubQ is well tolerated and maintains aesthetic correction of the cheeks and chin for at least 3 months after subcutaneous and/or supraperiostal treatment. | | Language | eng | | Pub Type(s) | Clinical Trial
Journal Article
Multicenter Study
| | PubMed ID | 16442040 |
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