| Title | Comparison of letrozole and clomiphene citrate in women with polycystic ovaries undergoing ovarian stimulation. |
| Author(s) | Atay V, Cam C, Muhcu M, Cam M, Karateke A |
| Institution | Obstetrics and Gynaecology Department, GATA Haydarpasa Training Hospital, Istanbul, Turkey. vedatatay@hotmail.com |
| Source | J Int Med Res 2006 Jan-Feb; 34(1):73-6. |
| MeSH | Adult
Clomiphene
Comparative Study
Female
Fertility Agents, Female
Humans
Infertility, Female
Nitriles
Ovulation Induction
Polycystic Ovary Syndrome
Pregnancy
Triazoles
|
| Abstract | Letrozole was compared with clomiphene citrate (CC) as a first-line treatment for ovulation induction in women with polycystic ovaries (PCOs). A total of 106 women with primary infertility and a diagnosis of PCOs were randomized to receive either 100 mg CC (n = 55) or 2.5 mg letrozole (n = 51) daily for 5 days. Human chorionic gonadotrophin (hCG) at a dose of 10000 IU was administered when at least one follicle with a mean diameter > or = 18 mm was observed using transvaginal ultrasound. The number of mature follicles was significantly lower, but endometrial thickness and ovulation and pregnancy rates were significantly higher in the letrozole group than in the CC group. In conclusion, letrozole is associated with a higher pregnancy rate than CC in PCO patients and may have a role as a first-line treatment for anovulatory patients with PCOs. |
| Language | eng |
| Pub Type(s) | Journal Article
Randomized Controlled Trial
|
| PubMed ID | 16604826 |
