Correlation between intraocular pressure, central corneal thickness, stage of glaucoma, and demographic patient data: prospective analysis of biophysical parameters in tertiary glaucoma practice populations. Journal of glaucoma. [J Glaucoma] Journal article | | Title | Correlation between intraocular pressure, central corneal thickness, stage of glaucoma, and demographic patient data: prospective analysis of biophysical parameters in tertiary glaucoma practice populations. | | Author(s) | Kniestedt C, Lin S, Choe J, Nee M, Bostrom A, Stürmer J, Stamper RL | | Institution | Department of Ophthalmology, University of California, San Francisco, CA, USA. Christoph@Kniestedt.ch | | Source | J Glaucoma 2006 Apr; 15(2):91-7. | | MeSH | Adolescent
Adult
African Continental Ancestry Group
Aged
Aged, 80 and over
Asian Continental Ancestry Group
Body Weights and Measures
Child
Cornea
Cross-Sectional Studies
European Continental Ancestry Group
Female
Glaucoma, Angle-Closure
Glaucoma, Open-Angle
Humans
Intraocular Pressure
Male
Middle Aged
Ocular Hypertension
Prospective Studies
Research Support, Non-U.S. Gov't
Switzerland
Tonometry, Ocular
United States
Visual Acuity
| | Abstract | PURPOSE: To determine the correlation of central corneal thickness (CCT) to Goldmann applanation tonometry (GAT) and dynamic contour tonometry (DCT, PASCAL), and to glaucoma stage as assessed by cup-to-disc ratio (CDR).
DESIGN: Prospective, cross-sectional tricenter observation study.
PATIENTS AND METHODS: From three glaucoma specialty practices a sample of 406 independent eyes was included. After ultrasound pachymetry, intraocular pressure was measured using PASCAL and Goldmann applanation tonometry and cup-to-disc ration was reassessed. Demographic data were included in the multivariate analysis.
RESULTS: Mean corneal thickness was 540 microm. African Americans and normal-tension glaucoma patients showed the lowest values (518 microm and 522 microm, respectively). These values were significantly thinner than the central corneal thickness of Caucasians (549 microm) and ocular hypertensives (564 microm). Intraocular pressure assessed by Goldmann applanation tonometry shows a significant correlation with central corneal thickness (r = 0.068, P < 0.001), whereas PASCAL is not significantly associated with central corneal thickness (r < 0.001, P = 0.997). Increased IOP is significantly correlated with large ocular pulse amplitudes (r = 0.13, P < 0.001), which is predominantly seen in ocular hypertensives. A significant negative correlation was detected between cup-to-disc ratio and central corneal thickness (r = 0.102, P < 0.001).
CONCLUSION: Glaucoma patients with thin central corneal thickness are more likely to be found at an advanced stage of the disease and among those with normal-tension glaucoma and black African ancestry. Underestimation of intraocular pressure by Goldmann applanation tonometry could be one causative factor. | | Language | eng | | Pub Type(s) | Journal Article
Multicenter Study
| | PubMed ID | 16633220 |
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