Gil-Agustí M, Carda-Broch S, Capella-Peiró ME, Esteve-Romero J
Micellar liquid chromatographic determination of five antianginals in pharmaceuticals. [Journal Article]
J Pharm Biomed Anal 2006 Jun 16; 41(4):1235-42.
A procedure was developed for the determination of five antianginals (diltiazem, nadolol, nifedipine, propranolol and verapamil), using hybrid micellar mobile phases of sodium dodecyl sulphate (SDS) and pentanol, a C18 column and UV detection. All possible combinations of antianginals were resolved and determined using a mobile phase of 0.05M SDS-5% pentanol with an analysis time of 9min. Repeatabilities and intermediate precision were evaluated at four different drug concentrations in the 2-20mug/ml (n=5) range. Limits of detection were in the range 0.028mug/ml for diltiazem and 0.130mug/ml for verapamil. The range of the limit of quantitation was from 0.092 to 0.431mug/ml for the same compounds. Antianginal drugs were studied in pharmaceuticals with no interference from related compounds. The results of the analyses of pharmaceuticals formulations were in agreement with the declared compositions.
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