| Title | Clinical value of autoantibodies against C1q in children with glomerulonephritis. | | Author(s) | Kozyro I, Perahud I, Sadallah S, Sukalo A, Titov L, Schifferli J, Trendelenburg M | | Institution | Department of Pediatrics, 2nd Children's Hospital, Belarus State University, Minsk, Belarus. | | Source | Pediatrics 2006 May; 117(5):1663-8. | | MeSH | Adolescent
Arthritis, Juvenile Rheumatoid
Autoantibodies
Biological Markers
Child
Child, Preschool
Complement C1q
Complement C3
Enzyme-Linked Immunosorbent Assay
Female
Glomerulonephritis
Humans
Lupus Nephritis
Male
Research Support, Non-U.S. Gov't
Streptococcal Infections
| | Abstract | OBJECTIVE: Autoantibodies against C1q (anti-C1q) have been found in a number of autoimmune and renal diseases. They are best described in adult patients with systemic lupus erythematosus, where a strong correlation between the occurrence of anti-C1q and severe lupus nephritis (LN) has been observed. However, the role of anti-C1q in children with systemic lupus erythematosus has not yet been determined. Furthermore, the clinical importance of anti-C1q in other forms of glomerulonephritis remains to be elucidated. The aim of this study was to investigate anti-C1q in children with different forms of glomerulonephritis including LN.
METHODS: We prospectively investigated 112 children with different forms of newly diagnosed glomerulonephritis for the presence of anti-C1q by an enzyme-linked immunosorbent assay and compared them with healthy controls. Associations between anti-C1q and disease manifestations at the time of the measurements and during follow-up were investigated.
RESULTS: Twenty-one of 112 patients were positive for anti-C1q compared with 0 of 40 healthy controls. Anti-C1q was associated with activity in LN and with disease severity in patients with acute poststreptococcal glomerulonephritis (APSGN). In LN, 7 of 12 patients were found to be anti-C1q positive. Six of these 7 had active disease at the time of the serum sampling compared with 1 of 5 of the anti-C1q-negative children. In children with APSGN, 8 of 24 were positive for anti-C1q. Anti-C1q-positive APSGN patients had significantly higher proteinuria and more often hypertension than those without anti-C1q. All 4 patients in which APSGN did not resolve spontaneously were anti-C1q positive.
CONCLUSIONS: Anti-C1q is associated with active LN in children. In addition, children with anti-C1q-positive APSGN have more severe disease than those who are anti-C1q negative. These data suggest APSGN is another disease in which anti-C1q has a pathogenic role. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 16651321 |
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