| Title | The comparative bioavailability of cimetidine-alginate treatments. |
| Author(s) | Britton AM, Nichols JD, Draper PR |
| Institution | Reckitt and Colman Pharmaceuticals, Kingston-Upon-Hull, UK. |
| Source | J Pharm Pharmacol 1991 Feb; 43(2):122-3. |
| MeSH | Administration, Oral
Adult
Alginates
Biological Availability
Cimetidine
Comparative Study
Drug Combinations
Female
Glucuronic Acid
Half-Life
Hemostatics
Hexuronic Acids
Humans
Male
|
| Abstract | The comparative bioavailability of cimetidine in cimetidine-alginate combinations has been investigated in twelve healthy volunteers in an open crossover study. Each volunteer received a single oral dose of a commercially available alginate-cimetidine combination tablet (Algitec) or cimetidine tablets (Tagamet), co-administered with a commercially available alginate reflux suppressant liquid or tablet (Gaviscon). No significant differences were observed between treatments for Cmax, tmax, AUC0-12 or AUC0- infinity. The study demonstrated equivalent bioavailability of cimetidine when administered separately with alginate products and as a fixed dose combination product. |
| Language | eng |
| Pub Type(s) | Journal Article
|
| PubMed ID | 1672897 |
