| Title | Development and reduction of hypertension and oxidative stress among detergent industry workers. | | Author(s) | Boojar MM, Goodarzi F, Boojar MM | | Institution | Department of Biology, University of Tarbiat Moalem Tehran, Iran. aboojar@yahoo.com | | Source | Arch Environ Health 2004 Dec; 59(12):700-10. | | MeSH | Adult
Biological Markers
Case-Control Studies
Detergents
Dust
Humans
Hypertension
Industry
Iran
Male
Malondialdehyde
Occupational Diseases
Occupational Exposure
Occupational Health
Oxidative Stress
Peptide Hydrolases
Questionnaires
Research Support, Non-U.S. Gov't
Risk Assessment
Risk Factors
| | Abstract | Hypertension status and oxidative stress parameters were assessed in 291 workers (hypertensive workers were divided into three grades, non-equivalently) at two detergent production plants, one of which included enzymes in the detergent (n=138) and another which did not (n=153), and 45 control workers in another industry three times (at the time of employment, 7 yrs later at the time of installation of a filter system, and about 3 yrs later). Malondialdehyde (MDA) was measured by high-performance liquid chromatography, antioxidant enzymes and lipid status by ultraviolet-visible spectrophotometry, trace elements by atomic absorption spectroscopy, and blood pressure using an oscilometric device. Prior to filter system installation, enzyme-exposed workers had significantly higher MDA, antioxidant enzyme activities, and prevalence of hypertension, compared with controls. The filter system reduced airborne detergent and enzyme dusts, resulting in a decreased prevalence of hypertension and a significant improvement in workers' oxidative stress indicators. Alterations in antioxidant status may result from the cumulative effect of high levels of detergent and enzyme in airborne dust in the workplace. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 16789480 |
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