Chemical Constituents of Malagasy Liverworts, Part V: Prenyl Bibenzyls and Clerodane Diterpenoids with Nitric Oxide Inhibitory Activity from Radula appressa and Thysananthus spathulistipus. [Chem Pharm Bull (Tokyo)] Journal article | | Title | Chemical Constituents of Malagasy Liverworts, Part V: Prenyl Bibenzyls and Clerodane Diterpenoids with Nitric Oxide Inhibitory Activity from Radula appressa and Thysananthus spathulistipus. | | Author(s) | Harinantenaina L, Takahara Y, Nishizawa T, Kohchi C, Soma GI, Asakawa Y | | Institution | Faculty of Pharmaceutical Sciences, Tokushima Bunri University. | | Source | Chem Pharm Bull (Tokyo) 2006; 54(7):1046-1049. | | Abstract | 3beta,4beta:15,16-Diepoxy-13(16),14-clerodadiene (1) and a new clerodane diterpenoid designated thysaspathone (2) were isolated from the liverwort Thysananthus spathulistipus, while Radula appressa produced radulannin A (3), radulannin L (4), 2-geranyl-3,5-dihydroxybibenzyl (5), 2(S)-2-methyl-2-(4-methyl-3-pentenyl)-7-hydroxy-5-(2-phenylethyl) chromene (o-cannabichromene) (6), 6-hydroxy-4-(2-phenylethyl) benzofuran (7), and o-cannabicyclol (8). All of the isolated compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and the greatest inhibition was attributed to compound 5, with an IC(50) value of 4.5 muM. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 16819230 |
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