| Title | ADIPONECTIN IN CHILDHOOD AND ADOLESCENT OBESITY AND ITS ASSOCIATION WITH INFLAMMATORY MARKERS AND COMPONENTS OF THE METABOLIC SYNDROME. | | Author(s) | Winer JC, Zern TL, Taksali SE, Dziura J, Cali AM, Wollschlager M, Seyal AA, Weiss R, Burgert TS, Caprio S | | Institution | Department of Pediatricsand the General Clinical Research Centerof the Yale University School of Medicine, New Haven, CT. | | Source | J Clin Endocrinol Metab 2006 Aug 22. | | Abstract | Context: Adiponectin levels are lower in obese children and adolescents, whereas markers of inflammation and pro-inflammatory cytokines are higher. Hypoadiponectinemia may contribute to the low-grade systemic chronic inflammatory state associated with childhood obesity.
Objective: We investigated whether C-reactive protein (CRP), the prototype of inflammation, is related to adiponectin levels independently of insulin resistance and adiposity. Design, Setting, Participants and Main Outcome Measures: In a multi-ethnic cohort of 589 obese children and adolescents, we administered a standard oral glucose tolerance test (OGTT) and obtained baseline measurements for adiponectin, plasma lipid profile, CRP, interleukin-6 (IL-6) and leptin.
Results: Stratifying the cohort into quartiles of adiponectin levels and adjusting for potential confounding variables, such as age, gender, ethnicity, BMI z-score, pubertal status, and insulin sensitivity, the present study revealed that low levels of adiponectin are associated not only with higher CRP levels, but also with components of the metabolic syndrome, such as low HDL-cholesterol and a high triglyceride-to-HDL ratio.
Conclusions: The link between adiponectin levels and a strong marker of inflammation, CRP, is independent of insulin resistance and adiposity in obese children and adolescents. Adiponectin may be one of the signals linking inflammation and obesity. Thus, adiponectin may function as a biomarker of the metabolic syndrome in childhood obesity. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 16926246 |
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