Collins BR, Gu X
Quantification of antihistamine acrivastine in plasma by solid-phase extraction and high-performance liquid chromatography. [JOURNAL ARTICLE]
J Pharm Biomed Anal 2006 Aug 21.
An automated solid-phase extraction method was developed for the determination of the H(1)-antihistamine acrivastine in plasma samples. Acrivastine was analyzed at the wavelength of 254nm using a reversed-phase HPLC assay. Both extraction procedure and analytical condition were optimized and validated for maximum recovery and resolution. The developed method was further applied to plasma samples collected from an in vivo pharmacokinetic study in rabbits. The assay was found to be simple, specific, accurate and reproducible.
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