| Title | Circulating Estradiol is an Independent Predictor of Progression of Carotid Artery Intima-Media Thickness in Middle-Aged Men. | | Author(s) | Tivesten A, Hulthe J, Wallenfeldt K, Wikstrand J, Ohlsson C, Fagerberg B | | Institution | Institute of Internal Medicine (Å.T., K.W., C.O., B.F.), The Wallenberg Laboratory for Cardiovascular Research (Å.T., J.H., K.W., J.W., B.F.), Sahlgrenska University Hospital, Göteborg University, Göteborg, Sweden, Medical Advisors at Astrazeneca (J.H., J.W.), Mölndal, Sweden and Dept of Clinical Pharmacology (C.O.), Sahlgrenska University Hospital, Göteborg University, Göteborg, Sweden. | | Source | J Clin Endocrinol Metab 2006 Aug 29. | | Abstract | Context: Estrogen treatment of men with prostate cancer is associated with increased cardiovascular morbidity and mortality; however, the role of endogenous estrogen levels for atherosclerotic disease in men is unknown.
Objective: To determine whether endogenous serum estradiol levels predict the progression of carotid artery intima-media thickness in men. Design, Setting and
Participants: Population-based, prospective cohort study (the Atherosclerosis and Insulin Resistance (AIR) study) conducted in Göteborg, Sweden among 313 Caucasian men without cardiovascular or other clinically overt diseases. Carotid artery intima-media thickness, an index of preclinical atherosclerosis, was measured by ultrasound at baseline (58 yr of age) and after 3 yr of follow-up. Serum sex hormone levels and cardiovascular risk factors (body-mass index, waist-to-hip ratio, systolic blood pressure, serum triglycerides, plasma c-peptide and smoking status) were assessed at study entry. Intervention: -- Main Outcome Measures: Association between baseline total and free estradiol levels and progression of carotid intima-media thickness over 3 yr with adjustments for cardiovascular risk factors.
Results: In univariate analyses, both total and free estradiol levels at baseline were positively associated with the annual change in intima-media thickness. In linear regression models including estradiol and cardiovascular risk factors, LDL and HDL cholesterol and estradiol were identified as independent predictors of progression of carotid artery intima-media thickness (total estradiol beta=0.187, P = 0.001 and free estradiol beta=0.183, P = 0.003).
Conclusions: Circulating estradiol is a predictor of progression of carotid artery intima-media thickness in middle-aged men. Further studies are needed to investigate the role of endogenous estradiol for incident cardiovascular disease events. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 16940451 |
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