| Title | Nuclear grooves. Valuable diagnostic feature in May-Grünwald-Giemsa-stained fine needle aspirates of papillary carcinoma of the thyroid. | | Author(s) | Bhambhani S, Kashyap V, Das DK | | Institution | Division of Cytopathology, Indian Council of Medical Research, Maulana Azad Medical College, New Delhi. | | Source | Acta Cytol 1990 Nov-Dec; 34(6):809-12. | | MeSH | Adenoma
Biopsy, Needle
Carcinoma
Carcinoma, Papillary
Cell Nucleus
Diagnosis, Differential
Eosine Yellowish-(YS)
Goiter
Humans
Methylene Blue
Staining and Labeling
Thyroid Neoplasms
Thyroiditis
| | Abstract | Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details. In the present study air-dried thyroid aspirates stained with the widely used May-Grünwald-Giemsa stain were evaluated. Nuclear grooves were observed in 88% of the May-Grünwald-Giemsa-stained aspirates from papillary thyroid carcinoma, usually in substantial numbers. A few grooved nuclei were seen in a small percentage of the other thyroid aspirates studied. These results show that nuclear grooves can also be used as a possible marker of papillary carcinoma of the thyroid in May-Grünwald-Giemsa-stained aspirates. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 1701601 |
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