| Title | Evidence for a link between parasite genotype and outcome of infection with Entamoeba histolytica. | | Author(s) | Ali IK, Mondal U, Roy S, Haque R, Petri WA, Clark CG | | Institution | Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, GB; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh; Division of Infectious Diseases and International Health, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia, USA. | | Source | J Clin Microbiol 2006 Nov 22. | | Abstract | The factors determining whether a person infected with Entamoeba histolytica develops disease remain obscure. To investigate whether the parasite genome contributes to the outcome we have investigated the distribution of parasite genotypes among E. histolytica-infected individuals in Bangladesh. Samples were obtained from individuals who were either asymptomatic, had diarrhea/dysentery, or had developed a liver abscess. Genotypes were determined using six tRNA-linked polymorphic markers and their distribution among the three sample groups evaluated. Significant population differentiation in genotype distribution was found for four of the six individual markers as well as for the combined genotypes, suggesting that the parasite genome does contribute in some way to the outcome of infection with E. histolytica. The markers themselves do not indicate the nature of the underlying genetic differences but they may be linked to loci that do have an impact on infection outcome. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 17122021 |
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