| Title | Rheumatologic complications of HIV infection. | | Author(s) | Reveille JD, Williams FM | | Institution | The University of Texas-Houston Health Science Center, MSB 5.270, 6431 Fannin, Houston, TX77030, USA. | | Source | Best Pract Res Clin Rheumatol 2006 Dec; 20(6):1159-79. | | Abstract | The pandemic caused by the human immunodeficiency virus (HIV) has entered its second quarter-century, with 40 million people now affected worldwide - particularly in Africa, where the impact has been most devastating. A complex array of rheumatic disease manifestations has been described, including diseases specific to HIV infection such as HIV-associated arthritis and the diffuse infiltrative lymphocytosis syndrome; other conditions which occur prominently in HIV-positive individuals include vasculitis, reactive and psoriatic arthritis and HIV-associated polymyositis, opportunistic musculoskeletal infections, and finally disorders that were originally ameliorated by HIV infection, such as rheumatoid arthritis and lupus. Effective antiretroviral treatment ameliorates many of these disorders; however, the introduction of highly active antiretroviral treatment (HAART) has introduced a new spectrum of disorders and new challenges confronting the clinician, including osteonecrosis, rhabdomyolysis, and, with immune reconstitution, the appearance de novo of a variety of autoimmune disorders and phenomena. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 17127202 |
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