| Title | Topical ketoprofen TDS patch versus diclofenac gel: efficacy and tolerability in benign sport related soft-tissue injuries. | | Author(s) | Esparza F, Cobián C, Jiménez JF, García-Cota JJ, Sánchez C, Maestro A, Working group for the acute pain study of SETRADE | | Institution | Centro Médico Juan XXIII, Murcia, Spain. fesparza@pdi.ucam.edu | | Source | Br J Sports Med 2007 Mar; 41(3):134-9. | | MeSH | Administration, Topical
Adolescent
Adult
Anti-Inflammatory Agents, Non-Steroidal
Athletic Injuries
Diclofenac
Female
Gels
Humans
Ketoprofen
Male
Middle Aged
Pain
Prospective Studies
Soft Tissue Injuries
Treatment Outcome
| | Abstract | OBJECTIVE: To compare the ketoprofen TDS patch with diclofenac gel in the treatment of traumatic acute pain in benign sport-related soft-tissue injuries.
DESIGN: 7-14 treatment days, prospective, randomised, open study.
PATIENTS: Outpatients aged 18-70 years diagnosed for painful benign sport-related soft-tissue injury (sprains, strains and contusions within the prior 48 h), randomised to either ketoprofen patch 100 mg once daily (n = 114) or diclofenac gel 2-4 g three times daily (n = 109).
INTERVENTION: 7-14 days of topical non-steroidal anti-inflammatory drugs treatment to assess the pain intensity changes (daily activities and spontaneous at rest) in a daily diary (100-mm Visual Analogue Scale (VAS)). Main outcome measurement: Pain intensity (VAS).
RESULTS: The ketoprofen patch was not inferior to diclofenac gel in reducing the baseline pain during daily activities (difference of -1.17 mm in favour of ketoprofen patch, 95% CI (-5.86 to 3.52), reducing to the baseline VAS 79%. Ketoprofen patch presented also a higher cure rate (64%) than diclofenac gel (46%) at day 7 (p = 0.004). Patient opinions about the treatment comfort (pharmaceutical shape, application and dosage) were also statistically higher for the ketoprofen patch (>80% of the patients rated as good or excellent the patch removal and skin adherence).
CONCLUSION: Ketoprofen patches are effective and safe pain relievers for the treatment of sports injury pain with advantages compared with diclofenac gel. | | Language | eng | | Pub Type(s) | Clinical Trial, Phase III
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
| | PubMed ID | 17138642 |
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