Zimmer C, Piepenbrink K, Riest G, Peters J
[Cardiotoxic and neurotoxic effects after accidental intravascular bupivacaine administration : Therapy with lidocaine propofol and lipid emulsion.] [JOURNAL ARTICLE]
Anaesthesist 2007 Feb 3.
Accidental intravascular administration of bupivacaine can cause severe neurotoxic and cardiotoxic effects. We report a case of suspected bupivacaine intoxication due to intravascular injection via an epidural catheter and treatment with lidocain, propofol, and a 20% lipid emulsion resulting in fast resolution of cardiotoxic and neurotoxic effects. Possible mechanisms of action of the medications used are discussed.
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