| Title | Cerebral sinus occlusion in a boy presenting with asparaginase-induced hypertriglyceridemia. | | Author(s) | Dietel V, Bührdel P, Hirsch W, Körholz D, Kiess W | | Institution | 1Hospital for Children and Adolescents, University of Leipzig Medical Center, Leipzig, Germany. | | Source | Klin Padiatr 2007 Mar-Apr; 219(2):95-6. | | Abstract | Cerebral sinus thrombosis is a rare but severe complication during treatment for acute lymphoblastic leukaemia (ALL). It mostly has been reported during treatment with asparaginase and dexamethasone. Hypertriglyceridemia has - albeit very rarely - also been associated with asparaginase therapy. The combination of cerebral sinus thrombosis and hypertriglyceridemia however, has not yet been reported. Here we describe a 15-year-old boy who presented with clinical symptoms and radiologic findings of a cerebral sinus thrombosis. In addition, a life-threatening hypertriglyceridemia was present. The complication was successfully treated by anticoagulation with low molecular weight heparin and the lipid regulator bezafibrate. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 17405075 |
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