| Title | Effect of Topical Emollient Treatment of Preterm Neonates in Bangladesh on Invasion of Pathogens Into the Bloodstream. | | Author(s) | Darmstadt GL, Saha SK, Ahmed NU, Choi Y, Chowdhury MA, Islam M, Law PA, Ahmed S | | Institution | Departments of International Health [G.L.D., Y.C.] and Population and Family Health Sciences [S.A.], Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205; Departments of Microbiology [S.K.S., M.I.] and Neonatology [A.S.M.N.U.A., M.A.K.A.C.], Bangladesh Institute of Child Health, Dhaka Shishu Hospital, Dhaka 1207, Bangladesh; Department of Pediatrics [A.S.M.N.U.A], Kumudini Womenʼs Medical College, Postal Code 1940, Mirzapur, Tangail, Bangladesh; Department of Informatics [P.A.L.], Kennedy Krieger Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21211. | | Source | Pediatr Res 2007 Mar 15. | | Abstract | Topical emollient therapy may reduce the incidence of serious infections and mortality of preterm infants in developing countries. We tested whether emollient therapy reduced the burden of pathogens on skin and/or prevented bacterial translocation. Neonates <33 wk gestational age were randomized to treatment with sunflower seed oil (SSO) or Aquaphor or the untreated control group. Skin condition score and skin cultures were obtained at enrollment and on d 3, 7, and weekly thereafter, and blood cultures were obtained for episodes of suspected nosocomial sepsis. For analysis, blood cultures were paired with skin cultures obtained 0-3 d before the blood culture. Skin condition scores at 3 d were better in patients treated with either emollient compared with untreated controls; however, skin flora was similar across the groups. The SSO group showed a 72% elevated odds of having a false-positive (FP) skin culture associated with a negative blood culture (i.e. skin flora blocked from entry into blood) compared with the control group. Topical therapy with SSO reduced the passage of pathogens from the skin surface into the bloodstream of preterm infants. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 17413870 |
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