| Title | Neurodevelopment of infants with single-suture craniosynostosis: presurgery comparisons with case-matched controls. | | Author(s) | Speltz ML, Kapp-Simon K, Collett B, Keich Y, Gaither R, Cradock MM, Buono L, Cunningham ML | | Institution | Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. mspeltz@u.washington.edu | | Source | Plast Reconstr Surg 2007 May; 119(6):1874-81. | | MeSH | Case-Control Studies
Child Behavior Disorders
Child, Preschool
Cranial Sutures
Craniosynostoses
Craniotomy
Developmental Disabilities
Female
Follow-Up Studies
Humans
Incidence
Infant
Male
Neuropsychological Tests
Postoperative Complications
Postoperative Period
Preoperative Care
Probability
Reference Values
Risk Assessment
Suture Techniques
| | Abstract | BACKGROUND: The hypothesized association between single-suture craniosynostosis and neurodevelopment remains unclear, given the methodologic limitations of previous studies, most notably the absence of control groups.
METHODS: Standardized measures were used to assess the neurodevelopment of 125 matched case-control pairs shortly after cases were first diagnosed with isolated fusions of the sagittal, metopic, lambdoid, or right or left coronal sutures. Participants varied in age from 2 to 24 months.
RESULTS: Cases had significantly lower mean standardized scores than controls on measures of cognitive ability and motor functioning (p < 0.02). These differences were unaffected by the location of synostosis, age of diagnosis, infant sex, and maternal IQ. Measures of early language functions revealed no group differences.
CONCLUSIONS: Before cranioplasty, single-suture craniosynostosis is associated with modest but reliable neurodevelopmental delays that cannot be attributed to maternal intelligence and family sociodemographic variables. Follow-up of this sample will determine the predictive significance of these delays. In the meantime, routine neurodevelopmental screening of infants with isolated craniosynostosis is recommended. | | Language | eng | | Pub Type(s) | Comparative Study
Journal Article
Research Support, N.I.H., Extramural
| | PubMed ID | 17440368 |
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