| Title | Risk assessment in haematopoietic stem cell transplantation: Impact of donor-recipient sex combination in allogeneic transplantation. | | Author(s) | Gahrton G | | Institution | Karolinska Institutet, Department of Medicine and Karolinska University Hospital, Huddinge, SE 14186 Stockholm, Sweden. | | Source | Best Pract Res Clin Haematol 2007 Jun; 20(2):219-29. | | Abstract | In allogeneic transplantation the donor-recipient sex combination plays a role in outcome. In large retrospective registry studies of several thousands of patients with aplastic anemia, chronic myelocytic leukemia (CML), acute myelocytic leukemia (AML), and multiple myeloma, chronic graft-versus-host disease (cGVHD) was more frequent and transplant-related mortality (TRM) higher in males with a female donor (F-->M) than in other donor-recipient sex combinations. Graft rejection was more frequent in females with a male donor (M-->F) in aplastic anemia, and a graft-versus-tumor effect (GVT) was documented as a reduced relapse rate in F-->M in CML, AML and multiple myeloma. The overall survival was adversely affected in F-->M in aplastic anemia, AML and CML and in M-->F in aplastic anemia. These results support the view that donor T cells specific for male minor histocompatiblity antigens encoded by Y-chromosome genes contribute to GVHD, graft rejection, GVT and survival in sex-mismatched transplants. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 17448958 |
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