| Title | Novel Lymphography Using Indocyanine Green Dye for Near-Infrared Fluorescence Labeling. | | Author(s) | Ogata F, Azuma R, Kikuchi M, Koshima I, Morimoto Y | | Institution | From the *Departments of Medical Engineering, †Plastic Surgery, and ‡Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan; and §Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. | | Source | Ann Plast Surg 2007 Jun; 58(6):652-655. | | Abstract | Lymphedema is known to be caused by many pathologic conditions; however, its diagnostic and therapeutic strategies remain to be unestablished. In this study, we investigated the usefulness of a novel lymphographic method based on fluorometric sensing using indocyanine green (ICG) dye for imaging lymphatic vessels using rat models. The real-time imaging system enabled visualization of superficial lymphatic vessels with a diameter of 0.1 mm in 33 frames/second. In addition, morphologic changes in lymphatic vessels in a radiation-induced lymphedema model were detected even at the latent stage. These results suggest that this imaging technique is acceptable as an evaluation method for the lymphatic system. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 17522489 |
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