Vasilakis N, Holmes EC, Fokam EB, Faye O, Diallo M, Sall AA, Weaver SC
EVOLUTIONARY PROCESSES AMONG SYLVATIC DENGUE-2 VIRUSES. [JOURNAL ARTICLE]
J Virol 2007 Jun 6.
Sylvatic dengue viruses (DENV) are transmitted in an enzootic cycle between non-human primates and arboreal Aedes mosquitoes in Southeast Asia and West Africa. Although previous analyses have revealed the evolutionary processes among endemic (human) DENV, little is known about viral evolution in the sylvatic cycle. Through an analysis of 14 complete coding regions of sylvatic DENV-2 virus sampled over a 33-year period, we show that both the rate of evolutionary change and pattern of natural selection are similar among endemic and sylvatic DENV, although the latter has a uniquely high frequency of positive selection in the NS4B protein gene. Our findings support a recent cross-species transmission event and suggest the possibility of future DENV re-emergence from the sylvatic cycle.
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