| Title | A new guinea pig model of cryptococcal meningitis. | | Author(s) | Kirkpatrick WR, Najvar LK, Bocanegra R, Patterson TF, Graybill JR | | Institution | Department of Medicine, The University of Texas Health Science Center at San Antonio, TX 78229-3900, and Audie Murphy Division, South Texas Veterans Health Care System, San Antonio, TX 78284. | | Source | Antimicrob Agents Chemother 2007 Jun 11. | | Abstract | We developed a guinea pig model of cryptococcal meningitis to evaluate antifungal agents. Immunosuppressed animals challenged intracranially with Cryptococcus neoformans responded to fluconazole and voriconazole. Disease was monitored by serial CSF cultures and quantitative organ cultures. Our model produces disseminating CNS disease, and responds to antifungal therapy. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 17562797 |
|
