| Title | [Study of debrisoquine hydroxylation polymorphism (CYP2D6) in the Cuban population compared to Spaniards.] | | Author(s) | González I, Pérez B, Alvarez M, Dorado P, Llerena A | | Institution | Hospital Psiquiátrico de La Habana. La Habana. Cuba. idilio@unex.es. | | Source | Med Clin (Barc) 2007 May 26; 128(20):772-4. | | Abstract | BACKGROUND AND
OBJECTIVE: CYP2D6 metabolic capacity shows genetic polymorphism. Two metabolic phenotypes, poor and extensive, can be determined by the ratio of debrisoquine to its metabolite in urine (MR). A subgroup of ultrarapids has been also described. We analyzed the inter-ethnic differences on the polymorphic hydroxylation of debrisoquine in a Cuban population in comparison to Spaniards. PATIENTS AND
METHOD: MR in a Cuban population of 260 white and mestizo healthy volunteers was studied and compared to 925 Spanish healthy volunteers.
RESULTS: The frequency of poor metabolizer in Cubans (4.6%) was almost identical to that found in Spaniards (4.9%). However, ultrarapids were lower in Cubans (3.8%) than in Spaniards (5.2%). MR in Cuban-mestizo extensive metabolizers was higher than in white (p < 0.05).
CONCLUSIONS: Interethnic differences on debrisoquine hydroxylation have been demonstrated in a Cuban population. Furthermore, differences on the frequency of ultrarapids between Cubans and Spaniards have been shown. These results could explain inter-individual and interethnic differences on drug response such as side effects or therapeutic failures among Cuban patients receiving treatment with CYP2D6 substrates. | | Language | spa | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 17568504 |
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