| Title | Oxidative stress markers and antioxidant status after oral iron supplementation to very low birth weight infants. | | Author(s) | Braekke K, Bechensteen AG, Halvorsen BL, Blomhoff R, Haaland K, Staff AC | | Institution | Pediatric Intensive Care Unit, Ulleval University Hospital, Oslo, Norway. kbre@uus.no | | Source | J Pediatr 2007 Jul; 151(1):23-8. | | MeSH | Administration, Oral
Antioxidants
Biological Markers
Cohort Studies
Confidence Intervals
Dietary Supplements
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Ferrous Compounds
Follow-Up Studies
Humans
Infant, Newborn
Infant, Very Low Birth Weight
Intensive Care Units, Neonatal
Male
Oxidative Stress
Probability
Prospective Studies
Risk Factors
Statistics, Nonparametric
Treatment Outcome
| | Abstract | OBJECTIVE: To evaluate whether our current practice of giving iron 18 mg daily to 6-week-old infants with very low birth weight (VLBW) was associated with increased oxidative stress markers or decreased antioxidant status.
STUDY DESIGN: The study was a prospective observational study of 21 healthy VLBW infants (born at gestational age <32 weeks, birth weight <1500 g). Blood and urine were sampled twice before starting iron supplementation at 6 weeks postnatal age and after 1 week of iron supplementation at age 7 weeks. Urine 8-isoprostane was analyzed by gas chromatography-mass spectrometry and plasma total hydroperoxides were measured. Antioxidant status was assessed by ascorbic acid (vitamin C), alpha-tocopherol (vitamin E), ferric-reducing ability of plasma, and plasma glutathione.
RESULTS: After 1 week of iron supplementation, no significant changes in urine 8-isoprostane or plasma total hydroperoxides were seen, and plasma antioxidants were largely unchanged.
CONCLUSIONS: Markers of oxidative stress in urine and plasma antioxidant status in healthy VLBW infants fed human milk remained unchanged after high-dose oral iron supplementation. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 17586185 |
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