| Title | Necrotizing gingivitis: a possible oral manifestation of ticlopidine-induced agranulocytosis. | | Author(s) | Rajandram RK, Ramli R, Karim F, Rahman RA, Fun LC | | Institution | Department of Oral and Maxillofacial Surgery, Faculty of Dentistry and Hospital Universiti Kebangsaan, Kuala Lumpur, Malaysia. r2tdh2004@yahoo.co.uk. | | Source | N Z Med J 2007; 120(1256):U2590. | | Abstract | Agranulocytosis is a rare complication of ticlopidine and can be life-threatening. We report a case of ticlopidine-induced agranulocytosis and neutropenia (neutrophil count of 0.1 x 10[9]/L) with necrotizing gingivitis in a 54-year-old Malaysian-Chinese female. She was started on ticlopidine 250 mg twice daily 3 weeks prior to this hospital admission. We started her on intravenous metronidazole and amoxicillin and clavulanic acid (Augmentin) and concurrently stopped ticlopidine. A series of clinical and laboratory investigations were carried out and a final diagnosis of necrotizing gingivitis possibly secondary to agranulocytosis was made. The patient was discharged home after 2 weeks of hospitalisation. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 17589558 |
|
