| Title | Management of type 2 diabetes mellitus associated with pituitary gigantism. | | Author(s) | Ali O, Banerjee S, Kelly DF, Lee PD | | Institution | Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA. | | Source | Pituitary 2007 Jul 13. | | Abstract | Pituitary gigantism, a condition of endogenous growth hormone (GH) hypersecretion prior to epiphyseal closure, is a rare condition. In the adult condition of GH excess, acromegaly, the occurrence of type 2 diabetes mellitus (T2DM) and diabetic ketoacidosis (DKA) have been reported, with resolution following normalization of GH levels. We report the case of a 16-year-old male with pituitary gigantism due to a large invasive suprasellar adenoma who presented with T2DM and DKA. Despite surgical de-bulking, radiotherapy and medical treatment with cabergoline and pegvisomant, GH and insulin-like growth factor-I (IGF-I) levels remained elevated. However, the T2DM and recurrent DKA were successfully managed with metformin and low-dose glargine insulin, respectively. We review the pathophysiology of T2DM and DKA in growth hormone excess and available treatment options. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 17629784 |
|
