Adaptation of a multi-drug resistant strain of Plasmodium falciparum from Peru to Aotus lemurinus griseimembra, A. nancymaae, and A. vociferans monkeys. The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] Journal article | | Title | Adaptation of a multi-drug resistant strain of Plasmodium falciparum from Peru to Aotus lemurinus griseimembra, A. nancymaae, and A. vociferans monkeys. | | Author(s) | Collins WE, Sullivan JS, Hall P, Ruebush TK, Williams A, Grady KK, Bounngaseng A, Nace D, Williams T, Huber C, Galland GG, Barnwell JW, Sullivan JJ | | Institution | Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention/USPHS/DHHS, 4770 Buford Highway, Chamblee, GA 30341, USA. wec1@cdc.gov | | Source | Am J Trop Med Hyg 2007 Aug; 77(2):261-5. | | Abstract | A strain of Plasmodium falciparum from Peru was adapted to splenectomized Aotus nancymaae and Aotus vociferans monkeys. The Peru 134/CDC strain of P. falciparum was shown to be resistant to treatment with chloroquine in monkeys and partially resistant to mefloquine and malarone. Genetic mutations in crt, dhfr, dhps, and cytochrome b genes conferring drug resistance were also determined for this Peruvian strain of P. falciparum. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
| | PubMed ID | 17690397 |
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