| Title | A randomized controlled comparison of family-based treatment and supportive psychotherapy for adolescent bulimia nervosa. | | Author(s) | le Grange D, Crosby RD, Rathouz PJ, Leventhal BL | | Institution | Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA. legrange@uchicago.edu | | Source | Arch Gen Psychiatry 2007 Sep; 64(9):1049-56. | | MeSH | Adolescent
Adolescent Psychology
Adult
Age Factors
Ambulatory Care
Attitude to Health
Bulimia Nervosa
Diagnostic and Statistical Manual of Mental Disorders
Family Therapy
Female
Follow-Up Studies
Humans
Male
Psychiatric Status Rating Scales
Psychotherapy
Regression Analysis
Treatment Outcome
| | Abstract | CONTEXT: Evidenced-based treatment trials for adolescents with bulimia nervosa are largely absent.
OBJECTIVE: To evaluate the relative efficacy of family-based treatment (FBT) and supportive psychotherapy (SPT) for adolescents with bulimia nervosa.
DESIGN: Randomized controlled trial.
SETTING: The University of Chicago from April 1, 2001, through June 30, 2006.
PARTICIPANTS: Eighty patients, aged 12 to 19 years, with a DSM-IV diagnosis of bulimia nervosa or a strict definition of partial bulimia nervosa.
INTERVENTIONS: Twenty outpatient visits over 6 months of FBT or SPT. Participants were followed up at 6 months posttreatment.
MAIN OUTCOME MEASURES: Abstinence from binge-and-purge episodes as measured by the Eating Disorder Examination. Secondary outcome measures were Eating Disorder Examination binge-and-purge frequency and Eating Disorder Examination subscale scores.
RESULTS: Forty-one patients were assigned to FBT and 39 to SPT. Categorical outcomes at posttreatment demonstrated that significantly more patients receiving FBT (16 [39%]) were binge-and-purge abstinent compared with those receiving SPT (7 [18%]) (P = .049). Somewhat fewer patients were abstinent at the 6-month follow-up; however, the difference was statistically in favor of FBT vs SPT (12 patients [29%] vs 4 patients [10%]; P = .05). Secondary outcome assessment, based on random regression analysis, revealed main effects in favor of FBT on all measures of eating pathological features (P = .003 to P = .03 for all).
CONCLUSIONS: Family-based treatment showed a clinical and statistical advantage over SPT at posttreatment and at 6-month follow-up. Reduction in core bulimic symptoms was also more immediate for patients receiving FBT vs SPT. | | Language | eng | | Pub Type(s) | Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
| | PubMed ID | 17768270 |
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