| Title | Identification of Type 2 Diabetes Genes in Mexican Americans Through Genome-wide Association Studies. | | Author(s) | Hayes MG, Pluzhnikov A, Miyake K, Sun Y, Ng MC, Roe CA, Below JE, Nicolae RI, Konkashbaev A, Bell GI, Cox NJ, Hanis CL | | Institution | Department of Medicine, The University of Chicago, Chicago, IL. | | Source | Diabetes 2007 Sep 10. | | Abstract | OBJECTIVE: To identify DNA polymorphisms associated with type 2 diabetes (T2D) in a Mexican American (MA) population.
RESEARCH DESIGN AND METHODS: We genotyped 116,204 single nucleotide polymorphisms (SNPs) in 281 MA with T2D and 280 random MA from Starr County, Texas using the Affymetrix GeneChip(R) Human Mapping 100K Set. Allelic association exact tests were calculated. Our most significant SNPs were compared to results from other T2D genome-wide association studies (GWAS). Proportions of African, European, and Asian ancestry were estimated from the HapMap samples using structure for each individual to rule out spurious association due to population substructure.
RESULTS: We observed more significant allelic associations than expected genome-wide as empirically assessed by permutation [14 below a p of 1x10(-4) (8.7 expected)]. No significant differences were observed between the proportion of ancestry estimates in the case and random control sets suggesting the association results were not likely confounded by substructure. A query of our top approximately 1% of SNPs (p<0.01) revealed SNPs in or near four genes that showed evidence for association (p<0.05) in multiple other GWAS interrogated: rs979752 and rs10500641 near UBQLNL and OR52H1 on chromosome 11, rs2773080 and rs3922812 in or near RALGPS2 on chromosome 1, and rs1509957 near EGR2 on chromosome 10.
CONCLUSIONS: We identified several SNPs with suggestive evidence for replicated association with T2D which merit further investigation. Abbreviations: | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 17846124 |
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