| Title | [Is surgery required for patients with isolated adrenal metastasis of non-small cell lung carcinoma?] | | Author(s) | Mercier O, Fadel E, Mussot S, Fabre D, Chataigner O, Chapelier A, Dartevelle P | | Institution | Service de chirurgie thoracique et vasculaire et de transplantation cardiopulmonaire, Hôpital Marie Lannelongue, Le Plessis Robinson (92). | | Source | Presse Med 2007 Sep 10. | | Abstract | BACKGROUND: No consensus yet governs management of solitary adrenal metastasis of non-small cell lung cancer (NSCLC). Although classically considered incurable, various case reports and small series indicate that surgical treatment may improve long-term survival. The aim of this study was to review our experience and to identify factors that may affect survival.
METHODS: From January 1989 through June 2006, 26 patients (21 men and 5 women; mean age: 54+/-10 years) underwent complete resection of an isolated adrenal metastasis after surgical treatment of NSCLC. The adrenal metastasis was diagnosed at the same time as the NSCLC in 6 patients and subsequently in 20 patients. Median disease-free interval for patients with metachronous metastasis was 13.8 months (range: 4.5 to 60.1 months).
RESULTS: The overall 5- and 10-year survival rates were 31 and 21% respectively. Univariate and multivariate analysis showed that a disease-free interval longer than 6 months was a significant independent predictor of longer survival in patients after adrenalectomy. All patients with a disease-free interval of less than 6 months died within 2 years of surgery. After resection of an isolated adrenal metastasis diagnosed more than 6 months after lung resection, the 5-year survival rate was 49%. Adjuvant therapy and pathological staging of NSCLC did not affect survival.
CONCLUSION: Surgical resection of subsequent isolated adrenal metastasis with a disease-free interval longer than 6 months can lead to long-term survival in patients with previous complete resection of the primary NSCLC. | | Language | FRE | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 17851028 |
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