| Title | Methotrexate delivery to the eye using transscleral hydrogel iontophoresis. | | Author(s) | Eljarrat-Binstock E, Domb AJ, Orucov F, Frucht-Pery J, Pe'er J | | Institution | Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. | | Source | Curr Eye Res 2007 Jul; 32(7):639-46. | | Abstract | Purpose: To evaluate methotrexate penetration and distribution profile in ocular structures after short low current transscleral hydrogel iontophoresis.
Methods: Methotrexate iontophoresis was studied in rabbits using drug-loaded hydrogels mounted on a portable iontophoretic device. Drug distribution profile was evaluated 2, 4, and 8 hours after iontophoretic treatment of 1.6 mA/cm(2) for 4 min. Ocular drug levels were also determined two hours after iontophoretic treatment of 5 mA/cm(2), compared to mock iontophoresis and intravitreal injection of methotrexate.
Results: Therapeutic drug levels were maintained for at least 8 h at the sclera and retina and for 2 h at the aqueous humor following the iontophoretic treatment. After increasing the current density, a twice-higher concentration was achieved at the vitreous and 8 to 20 time higher concentrations at the retina and sclera.
Conclusions: A short low current non-invasive iontophoretic treatment using methotrexate-loaded hydrogels has a potential clinical value in treating ocular inflammatory diseases and intraocular lymphoma. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 17852187 |
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