Balasubramaniam R, Lin PC, White DK, Yepes JF Resolution of an oral ulcer secondary to acetaminophen/hydrocodone withdrawal. [Journal Article] Gen Dent 2007 Sep-Oct; 55(5):441-4.
Acetaminophen/hydrocodone is a common non-opioid/opioid analgesic indicated for the treatment of moderate to severe pain. The following report depicts a unique case involving a 57-year-old woman with a persistent, painful oral ulcer that was unresponsive to standard treatments. The ulcer was resolved when the patient discontinued acetaminophen/hydrocodone use. The cause of the ulcer is unclear but it was speculated to result from a systemic hypersensitivity reaction to acetaminophen/hydrocodone.
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