| Title | Hemorrhagic disease of the newborn despite vitamin K prophylaxis at birth. | | Author(s) | Flood VH, Galderisi FC, Lowas SR, Kendrick A, Boshkov LK | | Institution | Division of Pediatric Hematology/Oncology, Oregon Health & Science University, Portland, Oregon. | | Source | Pediatr Blood Cancer 2007 Oct 23. | | Abstract | Late hemorrhagic disease of the newborn (HDN) presents 0.5-6 months after birth with mucocutaneous and intracranial bleeding. We describe here two cases of late HDN in infants who received vitamin K. The first case is a previously healthy breastfed male who received one dose of oral vitamin K at birth and developed an intracranial hemorrhage 5 weeks later. He was treated with intravenous vitamin K and recombinant factor VIIa prior to emergent craniectomy. An unrelated infant presented at 5 months of age with diarrhea and easy bruising despite IM vitamin K at birth. These cases illustrate the morbidity associated with late HDN. Pediatr Blood Cancer (c) 2007 Wiley-Liss, Inc. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 17957759 |
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